June 3, 2017
Mycosis fungoides Despite being the most common form of cutaneous T-cell lymphoma, mycosis fungoides (MF) is a rare disease. Rare case presentation has limited research and the clinical knowledge of physicians. Furthermore, vague dermatologic symptoms have led to frequent misdiagnosis and ill management. MF is a mature T cell non-Hodgkin lymphoma that primarily develops in the skin, but can also involve lymph nodes, blood, and other organs. Clinically, MF typically begins as variably sized, pruritic, erythematous patches with a fine scale. Although a small percentage of MF patients may progress to developing patches, nodules, and/or gradually enlarging tumors that can undergo necrosis and ulceration, most patients with MF do not progress beyond patch- or plaque -type disease. Patients with MF typically have a prolonged clinical course. Reference: Beigi, Pooya Khan Mohammad. Clinician’s Guide to Mycosis Fungoides. Springer, 2016.
June 3, 2017
Acrodermatitis Enteropathica Acrodermatitis Enteropathica (AE) is an inherited autosomal recessive disorder which often presents in newborn infants. This medical condition occurs as a result of mutation of a zinc transporter that affects the uptake of zinc in the intestine causing a decrease in the level of this elemental mineral in the blood. Prior to this knowledge, untreated AE was considered deleterious to the infant’s health and sometimes even fatal. Today however, the treatment involves adding zinc supplements to the patient’s diet which can easily improve the condition. Reference: Beigi, Pooya Khan Mohammad, and Emanual Maverakis. AE: A Clinician’s Guide. Springer, 2015.